Gui Zhi Fu Ling Wan for Fibroids: Benefits and Clinical Studies (2025)

Table of Contents

Composition of Gui Zhi Fu Ling Wan Mechanism of Action for Fibroids Clinical Evidence Side Effects and Contraindications This category is part of the Yo San University Master’s and Doctoral Degree Program

Acupuncture School Degree
Master’s and Doctorate of Acupuncture with a Chinese Herbal Medicine Specialization
Category: Chinese Herbal Medicine

Gui Zhi Fu Ling Wan (桂枝茯苓丸) is a classical herbal formula in Traditional Chinese Medicine (TCM), traditionally used for various gynecological conditions, including uterine fibroids. This formula has been in use for centuries, with its earliest record found in the ancient text “Jingui Yaolue” (Essential Prescriptions from the Golden Cabinet) by Zhang Zhongjing. It has been praised for its effectiveness in treating conditions related to blood stasis and phlegm accumulation, which, in TCM theory, are often implicated in the development of fibroids.

Composition of Gui Zhi Fu Ling Wan

Gui Zhi Fu Ling Wan consists of five primary herbs:

Mechanism of Action for Fibroids

In TCM, uterine fibroids are often seen as a result of blood stasis, sometimes with phlegm accumulation. Blood stasis refers to the impaired circulation of blood, leading to the formation of masses or lumps. Gui Zhi Fu Ling Wan is designed to address this stagnation and facilitate the movement of blood.

From a Western medical perspective, uterine fibroids are benign tumors composed of muscle and fibrous tissue that develop within the uterus. They are influenced by hormonal factors, particularly estrogen and progesterone. While the exact mechanism by which Gui Zhi Fu Ling Wan exerts its effects on fibroids is not fully understood in Western medicine, some proposed actions include:

Anti-inflammatory Effects: Studies have shown that components of the formula have anti-inflammatory properties, which may help reduce the size of fibroids by decreasing inflammation in the uterine tissue.
Antiproliferative Effects: Certain compounds within the formula may inhibit the proliferation of fibroid cells, contributing to a reduction in fibroid size.
Improvement of Uterine Blood Flow: By promoting blood circulation, the formula may help reduce the symptoms associated with fibroids, such as pain and heavy menstrual bleeding.

While clinical studies have shown promising results, it is important for individuals to consult with a qualified TCM practitioner before using this formula, particularly due to its potential side effects and contraindications. Additionally, combining this treatment with Western medical approaches under the guidance of healthcare professionals can provide a comprehensive strategy for managing fibroids.

Clinical Evidence

Several clinical studies have evaluated the effectiveness of Gui Zhi Fu Ling Wan in the treatment of uterine fibroids. Some key findings include:

Reduction in Fibroid Size: A number of studies have reported that women taking Gui Zhi Fu Ling Wan experienced a reduction in the size of their fibroids, as measured by ultrasound imaging.
Symptom Relief: Patients reported improvements in symptoms commonly associated with fibroids, such as menstrual irregularities, dysmenorrhea (painful menstruation), and pelvic pain.
Improved Quality of Life: By reducing symptoms, the formula has been shown to enhance the overall quality of life for women with fibroids.

Side Effects and Contraindications

Although Gui Zhi Fu Ling Wan is generally considered safe when used under the guidance of a qualified TCM practitioner, it is not without potential side effects and contraindications.

Side Effects:

Digestive Disturbances: Some individuals may experience mild gastrointestinal discomfort, such as nausea, diarrhea, or an upset stomach.
Allergic Reactions: Rarely, allergic reactions to one or more of the herbs in the formula can occur, presenting as rash, itching, or swelling.
Menstrual Changes: Since the formula acts on the blood and menstrual system, some women may experience changes in their menstrual cycle, including spotting or changes in flow.

Contraindications:

Pregnancy: Gui Zhi Fu Ling Wan is generally contraindicated during pregnancy due to its blood-moving properties, which may potentially affect the stability of the pregnancy. It is crucial for pregnant women to avoid this formula unless specifically prescribed by a knowledgeable TCM practitioner.
Active Hemorrhagic Disorders: Women with active bleeding disorders or who are taking anticoagulant medications should use this formula with caution, as it can enhance blood circulation and potentially exacerbate bleeding.
Heat or Yin Deficiency: In TCM, patients with signs of heat or yin deficiency (such as night sweats, hot flashes, or dry mouth) should use this formula cautiously, as it may aggravate these conditions.

Conclusion

Gui Zhi Fu Ling Wan remains a valuable formula in the TCM treatment of uterine fibroids, addressing the underlying pathologies of blood stasis and phlegm accumulation. Its combination of herbs works synergistically to promote blood flow, reduce stasis, and transform phlegm, potentially reducing the size of fibroids and alleviating associated symptoms.

Read More About Gui Zhi Fu Ling Wan and Fibroids

This category is part of the
Yo San University Master’s and Doctoral Degree Program

References

Zhang Zhongjing, “Jingui Yaolue” (Essential Prescriptions from the Golden Cabinet).
Jia, W., & Gao, W. (2003). Clinical application of Gui Zhi Fu Ling Wan in gynecology. Journal of Traditional Chinese Medicine.
Yu, J., Zheng, J., & Zhu, H. (2008). Treatment of uterine fibroids with Gui Zhi Fu Ling Wan: A clinical review. Chinese Medicine.
National Institute for Health and Care Excellence (NICE). (2018). Uterine fibroids: Diagnosis and management.

Written by Lauren Stomel, Chair of the Board, Yo San University
Lauren has been supporting the development of TCM for over 20 years and currently serves as the Chair of Yo San University.